Interactions between short latency afferent inhibition and long interval intracortical inhibition
Identifieur interne : 002091 ( Main/Exploration ); précédent : 002090; suivant : 002092Interactions between short latency afferent inhibition and long interval intracortical inhibition
Auteurs : Kaviraja Udupa [Canada] ; ZHEN NI [Canada] ; Carolyn Gunraj [Canada] ; Robert Chen [Canada]Source :
- Experimental brain research [ 0014-4819 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Nerf périphérique, Nerf moteur, Cortex moteur, Transmission cholinergique, Récepteur cholinergique, Récepteur gabaergique A, Récepteur gabaergique B, Muscle interosseux dorsal, Démence d'Alzheimer, Nerf médian, Poignet, Maladie de Parkinson, Stimulation magnétique transcrânienne, Stimulus magnétique, Homme.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Peripheral nerve stimulation inhibits the motor cortex and the process has been termed afferent inhibition. Short latency afferent inhibition (SAI) at interstimulus intervals (ISI) of ∼20 ms likely involves central cholinergic transmission and was found to be altered in Alzheimer's disease and Parkinson's disease. Cholinergic and GABAA receptors are involved in mediating SAI. The effects of SAI on other intracortical inhibitory and facilitatory circuits have not been examined. The objective of the present study is to test how SAI interacts with long interval cortical inhibition (LICI), a cortical inhibitory circuit likely mediated by GABAB receptors. We studied 10 healthy volunteers. Surface electromyogram was recorded from the first dorsal interosseous muscle. SAI was elicited by median nerve stimulation at the wrist followed by transcranial magnetic stimulation (TMS) at ISI of N20 somatosensory evoked potential latency + 3 ms. The effects of different test motor-evoked potential (MEP) amplitudes (0.2, 1, and 2 mV) were examined for LICI and SAI. Using paired and triple-pulse paradigms, the interactions between SAI and LICI were investigated. Both LICI and SAI decreased with increasing test MEP amplitude. Afferent stimulation that produced SAI decreased LICI. Thus, the present findings suggest that LICI and SAI have inhibitory interactions.
Affiliations:
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Street</s1><s2>Toronto, ON M5T 2S8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Zhen Ni" sort="Zhen Ni" uniqKey="Zhen Ni" last="Zhen Ni">ZHEN NI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1><s2>Toronto, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, University Health Network, MP 13-304, 399 Bathurst Street</s1><s2>Toronto, ON M5T 2S8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Gunraj, Carolyn" sort="Gunraj, Carolyn" uniqKey="Gunraj C" first="Carolyn" last="Gunraj">Carolyn Gunraj</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, University Health Network, MP 13-304, 399 Bathurst Street</s1><s2>Toronto, ON M5T 2S8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1><s2>Toronto, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Cholinergic receptor</term><term>Cholinergic transmission</term><term>Dorsal interosseous muscle</term><term>Gabaergic receptor A</term><term>Gabaergic receptor B</term><term>Human</term><term>Magnetic stimulus</term><term>Median nerve</term><term>Motor cortex</term><term>Motor nerve</term><term>Parkinson disease</term><term>Peripheral nerve</term><term>Transcranial magnetic stimulation</term><term>Wrist</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Nerf périphérique</term><term>Nerf moteur</term><term>Cortex moteur</term><term>Transmission cholinergique</term><term>Récepteur cholinergique</term><term>Récepteur gabaergique A</term><term>Récepteur gabaergique B</term><term>Muscle interosseux dorsal</term><term>Démence d'Alzheimer</term><term>Nerf médian</term><term>Poignet</term><term>Maladie de Parkinson</term><term>Stimulation magnétique transcrânienne</term><term>Stimulus magnétique</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Peripheral nerve stimulation inhibits the motor cortex and the process has been termed afferent inhibition. Short latency afferent inhibition (SAI) at interstimulus intervals (ISI) of ∼20 ms likely involves central cholinergic transmission and was found to be altered in Alzheimer's disease and Parkinson's disease. Cholinergic and GABA<sub>A</sub> receptors are involved in mediating SAI. The effects of SAI on other intracortical inhibitory and facilitatory circuits have not been examined. The objective of the present study is to test how SAI interacts with long interval cortical inhibition (LICI), a cortical inhibitory circuit likely mediated by GABA<sub>B</sub> receptors. We studied 10 healthy volunteers. Surface electromyogram was recorded from the first dorsal interosseous muscle. SAI was elicited by median nerve stimulation at the wrist followed by transcranial magnetic stimulation (TMS) at ISI of N20 somatosensory evoked potential latency + 3 ms. The effects of different test motor-evoked potential (MEP) amplitudes (0.2, 1, and 2 mV) were examined for LICI and SAI. Using paired and triple-pulse paradigms, the interactions between SAI and LICI were investigated. Both LICI and SAI decreased with increasing test MEP amplitude. Afferent stimulation that produced SAI decreased LICI. Thus, the present findings suggest that LICI and SAI have inhibitory interactions.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Udupa, Kaviraja" sort="Udupa, Kaviraja" uniqKey="Udupa K" first="Kaviraja" last="Udupa">Kaviraja Udupa</name></region><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Gunraj, Carolyn" sort="Gunraj, Carolyn" uniqKey="Gunraj C" first="Carolyn" last="Gunraj">Carolyn Gunraj</name><name sortKey="Udupa, Kaviraja" sort="Udupa, Kaviraja" uniqKey="Udupa K" first="Kaviraja" last="Udupa">Kaviraja Udupa</name><name sortKey="Zhen Ni" sort="Zhen Ni" uniqKey="Zhen Ni" last="Zhen Ni">ZHEN NI</name><name sortKey="Zhen Ni" sort="Zhen Ni" uniqKey="Zhen Ni" last="Zhen Ni">ZHEN NI</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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